Overdrive?
When you can hold speeds without downshifts, use OD.
When you need more rpm's, turn it off.
42RLE—Automatic, Four-Speed Overdrive
Gear Ratios 1st 2.84
Gear Ratios 2nd 1.57
Gear Ratios 3rd 1.0 <--OD Off
Gear Ratios 4th 0.69 <--OD
Gear Ratios Reverse 2.21
When you need more rpm's, turn it off.
42RLE—Automatic, Four-Speed Overdrive
Gear Ratios 1st 2.84
Gear Ratios 2nd 1.57
Gear Ratios 3rd 1.0 <--OD Off
Gear Ratios 4th 0.69 <--OD
Gear Ratios Reverse 2.21
Any place with a 3% or higher grade, turn OD off. This is assuming the stock 3.73's. The 3.21's I am really sorry if you live around mountains and haven't re-geared. My buddies rubi 4.1 is driveable in the Northwest with stock BFG's, 4.10's, and OD on.
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The OD off button is there for specific situations such as towing or off-road use where it is desirable to hold 3rd gear. It's good for engine braking or preventing the transmission from hunting between 3rd and 4th when climbing a long incline as well.
Otherwise just leave it on for best fuel economy.
Otherwise just leave it on for best fuel economy.



